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1

The selectivity of inhibitors of protein kinase CK2: an update

Pagano, Mario A., Bain, Jenny, Kazimierczuk, Zygmunt, Sarno, Stefania, Ruzzene, Maria, Di Maira, Giovanni, Elliott, Matthew, Orzeszko, Andrzej, Cozza, Giorgio, Meggio, Flavio, Pinna, Lorenzo A.

Journal:

Biochemical Journal

Year:

2008

Language:

english

File:

PDF, 963 KB

english, 2008

2

Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases

Cozza, Giorgio, Sarno, Stefania, Ruzzene, Maria, Girardi, Cristina, Orzeszko, Andrzej, Kazimierczuk, Zygmunt, Zagotto, Giuseppe, Bonaiuto, Emanuela, Di Paolo, Maria Luisa, Pinna, Lorenzo A.

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2013

Language:

english

File:

PDF, 1.08 MB

english, 2013

3

2-Aza-2′-deoxyadenosine: Synthesis, Base-Pairing Selectivity, and Stacking Properties of Oligonucleotides

Tamizi Sugiyama, Enno Schweinberger, Zygmunt Kazimierczuk, Natalya Ramzaeva, Helmut Rosemeyer, Frank Seela

Journal:

Chemistry - A European Journal

Year:

2000

Language:

english

File:

PDF, 181 KB

english, 2000

4

Studies on the Adamantylation of N-Heterocycles and Nucleosides

Zygmunt Kazimierczuk, Andrzej Orzeszko

Journal:

Helvetica Chimica Acta

Year:

1999

Language:

english

File:

PDF, 103 KB

english, 1999

5

Adamantylsulfanyl- and N-Adamantylcarboxamido-Derivatives of Heterocycles and Phenoles: Synthesis, Crystal Structure, Tumor Necrosis Factor-α Production-Enhancing Properties, and Theoretical Considerations

Jan Krzysztof Maurin, Witold Lasek, Agata Górska, Tomasz Świtaj, Anna Beata Jakubowska, Zygmunt Kazimierczuk

Journal:

Chemistry & Biodiversity

Year:

2004

Language:

english

File:

PDF, 500 KB

english, 2004

6

Hoogsteen vs. Watson–Crick Base Pairing: Incorporation of 2-Substituted Adenine- and 7-Deazaadenine 2′-Deoxy-β-D-ribonucleosides into Oligonucleotides

Natalya Ramzaeva, Elisabeth Michalek, Zygmunt Kazimierczuk, Frank Seela, Helmut Rosemeyer

Journal:

Chemistry & Biodiversity

Year:

2007

Language:

english

File:

PDF, 300 KB

english, 2007

7

Pteridine, LXVII. Synthese und Eigenschaften von Mono-, Di-und Trithio-Derivaten des 7-Hydroxy-1,3-dimethyllumazins

Zygmunt Kazimierczuk, Wolfgang Pfleiderer

Journal:

European Journal of Inorganic Chemistry

Year:

1979

File:

PDF, 843 KB

1979

8

The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules

Roberto Battistutta, Marco Mazzorana, Laura Cendron, Andrea Bortolato, Stefania Sarno, Zygmunt Kazimierczuk, Giuseppe Zanotti, Stefano Moro, Lorenzo A. Pinna

Journal:

Year:

2007

Language:

english

File:

PDF, 578 KB

english, 2007

9

ChemInform Abstract: Adamantylaminopyrimidines and -pyridines Are Potent Inducers of Tumor Necrosis Factor-α.

Zygmunt Kazimierczuk, Agata Gorska, Tomasz Switaj, Witold Lasek

Journal:

Year:

2001

Language:

english

File:

PDF, 32 KB

english, 2001

10

ChemInform Abstract: Microwave Induced Synthesis of Ribonucleosides on Solid Support.

Mariola Andrzejewska, Jaroslaw Kaminski, Zygmunt Kazimierczuk

Journal:

Year:

2002

File:

PDF, 27 KB

2002

11

Synthesis, Antiprotozoal and Anticancer Activity of Substituted 2-Trifluoromethyl- and 2-Pentafluoroethylbenzimidazoles.

Mariola Andrzejewska, Lilian Yepez-Mulia, Roberto Cedillo-Rivera, Amparo Tapia, Leena Vilpo, Juhani Vilpo, Zygmunt Kazimierczuk

Journal:

Year:

2003

File:

PDF, 138 KB

2003

12

Microwave-Assisted Synthesis of O′-Adamantylated Uracil-Derived Nucleosides.

Agata Gorska, Mariola Andrzejewska, Jaroslaw Kaminski, Zygmunt Kazimierczuk

Journal:

Year:

2003

File:

PDF, 97 KB

2003

13

Novel Adamantylated Pyrimidines and Their Preliminary Biological Evaluations.

Barbara Orzeszko, Zygmunt Kazimierczuk, Jan Krzysztof Maurin, Agnieszka Ewa Laudy, Bohdan Jerzy Starosciak, Juhani Vilpo, Leena Vilpo, Jan Balzarini, Andrzej Orzeszko

Journal:

Year:

2005

File:

PDF, 26 KB

2005

14

Synthesis of 8-Aza-2′-deoxyadenosine and related 7-Amino-3H-1,2,3-triazolo[4,5-d]pyrimidine 2′-Deoxyribofuranosides: Stereoselective glycosylation via the nucleobase anion

Zygmunt Kazimierczuk, Uwe Binding, Frank Seela

Journal:

Helvetica Chimica Acta

Year:

1989

Language:

english

File:

PDF, 613 KB

english, 1989

15

Synthesis of 8-Aza-1,3-dideaza-2′-deoxyadenosine and 5,6-Disubstituted Benzotriazole 2′-Deoxy-β-D-Ribofuranosides via Nucleobase-Anion Glycosylation

Zygmunt Kazimierczuk, Frank Seela

Journal:

Helvetica Chimica Acta

Year:

1990

Language:

english

File:

PDF, 631 KB

english, 1990

16

2′-Deoxyisoguanosine and Base-Modified Analogues: Chemical and Photochemical Synthesis

Zygmunt Kazimierczuk, Ralf Mertens, Wieslaw Kawczynski, Frank Seela

Journal:

Helvetica Chimica Acta

Year:

1991

Language:

english

File:

PDF, 376 KB

english, 1991

17

Pteridines. Part XCVII. Synthesis and properties of 6-thioxanthopterin and 7-thioisoxanthopterin

Detlev Mohr, Zygmunt Kazimierczuk, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1992

Language:

english

File:

PDF, 474 KB

english, 1992

18

Base-Modified Nucleosides Related to 2-Chloro-2′-deoxyadenosine

Zygmunt Kazimierczuk, Juhani A. Vilpo, Frank Seela

Journal:

Helvetica Chimica Acta

Year:

1992

Language:

english

File:

PDF, 464 KB

english, 1992

19

Synthesis of Phosphonates and Oligodeoxyribonucleotides Derived from 2′-Deoxyisoguanosine and 2′-Deoxy-2-haloadenosines

Frank Seela, Ralf Mertens, Zygmunt Kazimierczuk

Journal:

Helvetica Chimica Acta

Year:

1992

Language:

english

File:

PDF, 512 KB

english, 1992

20

Synthesis of 2′-Deoxyisoinosine and Related 2′-Deoxyribonucleosides

Frank Seela, Yaoming Chen, Uwe Bindig, Zygmunt Kazimierczuk

Journal:

Helvetica Chimica Acta

Year:

1994

Language:

english

File:

PDF, 563 KB

english, 1994

21

Substituent Reactivity and Tautomerism of Isoguanosine and Related Nucleosides

Frank Seela, Changfu Wei, Zygmunt Kazimierczuk

Journal:

Helvetica Chimica Acta

Year:

1995

Language:

english

File:

PDF, 717 KB

english, 1995

22

Nucleoside, XXXVIII. Synthese und Eigenschaften von 1-(β-D-Ribofuranosyl)-2-chinoxalinonen und -2,3-chinoxalindionen

Zygmunt Kazimierczuk, Wolfgang Pfleiderer

Journal:

European Journal of Organic Chemistry

Year:

1982

Language:

german

File:

PDF, 434 KB

german, 1982

23

Stereoselective synthesis of 2-azapurine 2′-deoxy-β-D-ribonucleosides by nucleobase-anion glycosylation

Zygmunt Kazimierczuk, Frank Seela

Journal:

European Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 457 KB

english, 1990

24

Synthesis of 5-amino-4-cyano-1-imidazolyl 2-Deoxy-β-D-ribofuranoside by photolysis of 2-aza-2′-deoxyadenosine or glycosylation

Zygmunt Kazimierczuk, Frank Seela

Journal:

European Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 274 KB

english, 1991

25

Synthesis and Properties of Methylthiopyrazolo[3,4-d]pyrimidine 2′-Deoxy-β-D-ribonucleosides

Frank Oertel, Holger Winter, Zygmunt Kazimierczuk, J. A. Vilpo, Peter Richter, Frank Seela

Journal:

European Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 549 KB

english, 1992

26

Inspecting the Structure-Activity Relationship of Protein Kinase CK2 Inhibitors Derived from Tetrabromo-Benzimidazole

Roberto Battistutta, Marco Mazzorana, Stefania Sarno, Zygmunt Kazimierczuk, Giuseppe Zanotti, Lorenzo A. Pinna

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 308 KB

english, 2005

27

Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2

Alessandra Gianoncelli, Giorgio Cozza, Andrzej Orzeszko, Flavio Meggio, Zygmunt Kazimierczuk, Lorenzo A. Pinna

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 442 KB

english, 2009

28

Molecular structure of 2-chloro-2′-deoxyadenosine an agent used in therapy for multiple sclerosis and its unusual crystal packing mode

Gertraud Koellner, Zygmunt Kazimierczuk, Thomas Steiner, Jaroslaw Kaminski

Journal:

Journal of Molecular Structure

Year:

1998

Language:

english

File:

PDF, 349 KB

english, 1998

29

Anodic decarboxylative oxidation of carboxymethyluracil and -thymine isomers

Jaroslaw Kamiński, Maria Pachulska, Ryszard Stolarski, Zygmunt Kazimierczuk

Journal:

Year:

1997

Language:

english

File:

PDF, 341 KB

english, 1997

30

The novel product of cathodic reduction of phthalimide anion

Andrzej Orzeszko, Jan K. Maurin, Anna Niedźwiecka-Kornaś, Zygmunt Kazimierczuk

Journal:

Year:

1998

Language:

english

File:

PDF, 344 KB

english, 1998

31

Synthesis, antiprotozoal and anticancer activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles

Mariola Andrzejewska, Lilián Yépez-Mulia, Roberto Cedillo-Rivera, Amparo Tapia, Leena Vilpo, Juhani Vilpo, Zygmunt Kazimierczuk

Journal:

European Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 274 KB

english, 2002

32

Adamantylaminopyrimidines and -pyridines are potent inducers of tumor necrosis factor-α

Zygmunt Kazimierczuk, Agata Górska, Tomasz Świtaj, Witold Lasek

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 287 KB

english, 2001

33

Polyhalogenobenzimidazoles: synthesis and Their inhibitory activity against casein kinases

Mariola Andrzejewska, Mario A Pagano, Flavio Meggio, Anna Maria Brunati, Zygmunt Kazimierczuk

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 198 KB

english, 2003

34

Susceptibility in vitro of clinically metronidazole-resistantTrichomonas vaginalisto nitazoxanide, toyocamycin, and 2-fluoro-2′-deoxyadenosine

Janelle M. Wright, Linda A. Dunn, Zygmunt Kazimierczuk, Anita G. Burgess, Kenia G. Krauer, Peter Upcroft, Jacqueline A. Upcroft

Journal:

Parasitology Research

Year:

2010

Language:

english

File:

PDF, 198 KB

english, 2010

35

Novel and promising compounds to treatCryptosporidium parvuminfections

Zofi Graczyk, Lidia Chomicz, Mariola Kozłowska, Zygmunt Kazimierczuk, Thaddeus K. Graczyk

Journal:

Parasitology Research

Year:

2011

Language:

english

File:

PDF, 136 KB

english, 2011

36

Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro

Hanna Lawnicka, Magdalena Kowalewicz-Kulbat, Paulina Sicinska, Zygmunt Kazimierczuk, Pawel Grieb, Henryk Stepien

Journal:

Cell and Tissue Research

Year:

2010

Language:

english

File:

PDF, 289 KB

english, 2010

37

Synthesis and antimicrobial and nitric oxide synthase inhibitory activities of novel isothiourea derivatives

Zygmunt Kazimierczuk, Malgorzata Chalimoniuk, Agnieszka Ewa Laudy, Rosa Moo-Puc, Roberto Cedillo-Rivera, Bohdan Jerzy Starosciak, Stanislaw J. Chrapusta

Journal:

Archives of Pharmacal Research

Year:

2010

Language:

english

File:

PDF, 471 KB

english, 2010

38

Convergent syntheses and cytostatic properties of 2-chloro-2′-deoxy-2′-fluoroadenosine and its N7-isomer

Galina V. Zaitseva, Grigorii G. Sivets, Zygmunt Kazimierczuk, Juhani A. Vilpo, Igor A. Mikhailopulo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 220 KB

english, 1995

39

Anti-Pentatrichomonas hominisactivity of newly synthesized benzimidazole derivatives —in vitrostudies

Lidia Chomicz, Marcin Padzik, Agnieszka E. Laudy, Mariola Kozłowska, Anna Pietruczuk, Janusz Piekarczyk, Nadine Godineau, Gabriela Olędzka, Zygmunt Kazimierczuk

Journal:

Acta Parasitologica

Year:

2009

Language:

english

File:

PDF, 290 KB

english, 2009

40

Synthesis of 2'-deoxytubercidin, 2'-deoxyadenosine, and related 2'-deoxynucleosides via a novel direct stereospecific sodium salt glycosylation procedure

Kazimierczuk, Zygmunt, Cottam, Howard B., Revankar, Ganapathi R., Robins, Roland K.

Journal:

Journal of the American Chemical Society

Year:

1984

Language:

english

File:

PDF, 588 KB

english, 1984

41

CK2α and CK2α′ subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives

Monika Janeczko, Andrzej Orzeszko, Zygmunt Kazimierczuk, Ryszard Szyszka, Andrea Baier

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 316 KB

english, 2012

42

Synthesis, and antiprotozoal and antibacterial activities of S-substituted 4,6-dibromo- and 4,6-dichloro-2-mercaptobenzimidazoles

Mariola Andrzejewska, Lilian Yepez-Mulia, Amparo Tapia, Roberto Cedillo-Rivera, Agnieszka E. Laudy, Bohdan J. Starościak, Zygmunt Kazimierczuk

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 107 KB

english, 2004

43

Novel adamantylated pyrimidines and their preliminary biological evaluations

Barbara Orzeszko, Zygmunt Kazimierczuk, Jan Krzysztof Maurin, Agnieszka Ewa Laudy, Bohdan Jerzy Starościak, Juhani Vilpo, Leena Vilpo, Jan Balzarini, Andrzej Orzeszko

Journal:

Year:

2004

Language:

english

File:

PDF, 434 KB

english, 2004

44

Selective activation of deoxycytidine kinase by thymidine-5′-thiosulphate and release by deoxycytidine in human lymphocytes

Gergely Keszler, Karoly Szikla, Zygmunt Kazimierczuk, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely, Maria Staub

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 194 KB

english, 2003

45

Effect of gamma-irradiation on cladribine and cladribine-containing biodegradable copolymers

Tomasz Kryczka, Barbara Marciniec, Maria Popielarz-Brzezinska, Maciej Bero, Janusz Kasperczyk, Piotr Dobrzyński, Zygmunt Kazimierczuk, Paweł Grieb

Journal:

Journal of Controlled Release

Year:

2003

Language:

english

File:

PDF, 342 KB

english, 2003

46

Preparation and Properties of an Analogue of Poly(A) and Poly(G): Poly(isoguanylic acid)

Teresa GOLAṠ, Magdalena FIKUS, Zygmunt KAZIMIERCZUK, David SHUGAR

Journal:

Year:

1976

Language:

english

File:

PDF, 745 KB

english, 1976

47

2-Chloro-2′ -deoxyadenosine (Cladribine) and its Analogues are Good Substrates and Potent Selective Inhibitors of Escherichia coli Purine-Nucleoside Phosphorylase

Agnieszka Bzowska, Zygmunt Kazimierczuk

Journal:

Year:

1995

Language:

english

File:

PDF, 510 KB

english, 1995

48

Preparation and Properties of the 5,6- and 4,6(5,7)-Dinitro Derivatives of Benzimidazole and their 1-β-D-Ribofuranosides

Kazimierczuk, Zygmunt, Shugar, David

Journal:

Nucleosides and Nucleotides

Year:

1989

Language:

english

File:

PDF, 327 KB

english, 1989

49

Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs

Jan Tebbe, Agnieszka Bzowska, Beata Wielgus-Kutrowska, Werner Schröder, Zygmunt Kazimierczuk, David Shugar, Wolfram Saenger, Gertraud Koellner

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 570 KB

english, 1999

50

2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2

Mario A. Pagano, Flavio Meggio, Maria Ruzzene, Mariola Andrzejewska, Zygmunt Kazimierczuk, Lorenzo A. Pinna

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 309 KB

english, 2004